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目的：了解上海地区慢性阻塞性肺疾病（ Ｃ Ｏ Ｐ Ｄ）中流感嗜血杆菌（ Ｈ Ｉ）感染的发病情况、药物敏感性及临床特点。方法：以改良哥伦比亚巧克力琼脂作为分离培养基，分别以纸片（ Ｋ Ｂ）法和肉汤微量稀释法测定各种抗生素的敏感性，分析 Ｃ Ｏ Ｐ Ｄ患者 Ｈ Ｉ感染的临床特点。结果：在４２１ 例 Ｃ Ｏ Ｐ Ｄ急性加重的患者中，分离出致病菌２２９ 株，其中４５ 株（１９．７％ ）为 Ｈ Ｉ；患者临床表现主要为肺部一般炎症；第３ 代头孢菌素和喹诺酮类抗生素抗菌活性高，氨苄西林的耐药率达 ２２．２％ 。结论： Ｈ Ｉ感染是 Ｃ Ｏ Ｐ Ｄ急性加重的主要原因之一，其临床特点无特异性。喹诺酮类、第３ 代头孢菌素等抗生素对 Ｈ Ｉ抗菌活性较高。
Objective: To investigate the incidence, drug sensitivity and clinical features of Haemophilus influenzae (H I) infection in chronic obstructive pulmonary disease (COPD) in Shanghai. Methods: The modified chocolate Columbia agar was used as the separation medium. The antibiotic susceptibility was determined by KB method and broth microdilution method respectively. The clinical features of H I infection in C O P D were analyzed. Results: Among 421 patients with acute exacerbation of COPD, 229 strains of pathogens were isolated, of which 45 (19.7%) were H I; the clinical manifestations of the patients were mainly general lung inflammation; the third generation of cephalosporins Mycotoxin and quinolone antibiotics antibacterial activity, ampicillin resistance rate of 22.2%. Conclusion: H I infection is one of the major causes of acute exacerbation of COPD, and its clinical features are not specific. Quinolones, third-generation cephalosporins and other antibiotics have a high antibacterial activity against H I.