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目的：探讨非小细胞肺癌（ＮＳＣＬＣ）肿瘤新生血管与生物学行为和预后的关系。方法：随访１９８５～１９９１年间８５例原发性非小细胞肺癌术后病例，采用Ⅷ因子相关抗原免疫组化显示新生血管对其病例进行研究。结果：病人的平均年龄５５．６±８．４岁，３年、５年总体生存率分别为６６％和６１％，中位随访时间为４７个月。有淋巴结转移病人平均微血管数目为８０±３７．９，无淋巴结转移病人平均微血管数目为６５．６±３４．３，两组之间有差别（Ｆ＝３．１１，Ｐ＜０．０５）。在３１例腺癌中，有淋巴结转移组微血管数目为１０７．８±３７．３，无淋巴结转移组微血管数目为６３．９±３２．７，两组之间有显著性差别（Ｆ＝１０．５４，Ｐ＜０．０１），单变量生存分析显示，随着微血管数目的增加，病人的生存率明显下降（Ｐ＜０．０１）。结论：新生血管密度与非小细胞肺癌（ＮＳＣＬＣ）的生物学行为有关并有重要的预后意义。
Objective: To investigate the relationship between neovascularization, biological behavior and prognosis of non-small cell lung cancer (NSCLC). Methods: Follow-up cases of 85 patients with primary non-small cell lung cancer were followed up from 1985 to 1991. VIII factor-associated antigen was used to immunohistochemically show neovascularization to study the cases. Results: The average age of the patients was 55.6±8.4 years. The 3-year and 5-year overall survival rates were 66% and 61%, respectively. The median follow-up time was 47 months. The average number of microvessels in patients with lymph node metastases was 80±37.9, and the average number of microvessels in patients without lymphatic metastasis was 65.6±34.3. There was a difference between the two groups (F=3.11, P<0.05). In 31 cases of adenocarcinoma, the number of microvessels with lymph node metastasis was 107.8±37.3, and the number of microvessels without lymphatic metastasis was 63.9±32.7. There was a significant difference between the two groups (F=10. 54,P<0.01), univariate survival analysis showed that with the increase in the number of microvessels, the patient’s survival rate decreased significantly (P<0.01). CONCLUSIONS: Neovascular density is associated with the biological behavior of non-small cell lung cancer (NSCLC) and has important prognostic significance.