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目的:考察丙种球蛋白静脉滴注联合干扰素雾化吸入治疗儿童重症手足口病的临床疗效,供临床参考。方法:选取2013年1月至2016年7月我院收治的重症手足口病患儿90例,采用随机数表法分为对照组和观察组各45例。对照组采用干扰素雾化吸入治疗,观察组采用丙种球蛋白静脉滴注联合干扰素雾化吸入治疗,治疗5 d后比较两组的临床疗效。结果:观察组退热时间、疱疹消失时间、口腔炎愈合时间、神经受累时间及住院时间均短于对照组(P均<0.05)。观察组治疗5 d后,血清IL-6、TNF-α均低于对照组(P均<0.05);IGF-1、CD3、CD4、CD4/CD8水平均高于对照组(P均<0.05)。观察组不良反应发生率低于对照组(P<0.05)。结论:丙种球蛋白静脉滴注联合干扰素雾化吸入治疗儿童重症手足口病效果理想,值得推广应用。
Objective: To investigate the clinical efficacy of intravenous gamma globulin infusion and interferon nebulization in the treatment of severe hand-foot-mouth disease in children for clinical reference. Methods: From January 2013 to July 2016, 90 children with severe hand-foot-mouth disease admitted to our hospital were divided into control group and observation group with 45 cases in each group. The control group was treated with interferon nebulized inhalation, the observation group was treated with intravenous gamma globulin infusion combined with interferon nebulized inhalation, and the clinical efficacy was compared between the two groups after 5 days of treatment. Results: The antipyretic time, disappearance of herpes, stomatitis healing time, nerve involvement time and hospital stay in observation group were shorter than those in control group (all P <0.05). The levels of IL-6 and TNF-α in the observation group were lower than those in the control group (P <0.05), and the levels of IGF-1, CD3, CD4 and CD4 / CD8 in the observation group were higher than those in the control group . The incidence of adverse reactions in the observation group was lower than that in the control group (P <0.05). Conclusion: Intravenous infusion of gamma globulin combined with interferon nebulization is an ideal treatment for severe hand-foot-mouth disease in children and it is worth popularizing and applying.