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目的:为医师选择降压药提供参考。方法:比较370例原发性高血压患者应用6类15种单药治疗的降压疗效。结果:除多沙唑嗪外,各单药均有效降压;多沙唑嗪和托拉塞米降舒张压的效果较逊。结论:长效钙拮抗药、血管紧张素转换酶抑制剂、血管紧张素受体拮抗药以及特拉唑嗪、吲达帕胺均能单药有效降压。低剂量多沙唑嗪和托拉塞米不建议单独使用治疗高血压。
Objective: To provide reference for doctors to choose antihypertensive drugs. METHODS: The antihypertensive efficacy of sixteen classes of 15 monotherapy in 370 patients with essential hypertension was compared. Results: In addition to doxazosin, the single drug were effective antihypertensive; doxazosin and torasemide decreased diastolic blood pressure less effective. CONCLUSION: Long-acting calcium antagonists, angiotensin converting enzyme inhibitors, angiotensin receptor antagonists, and terazosin and indapamide are both effective in lowering blood pressure. Low-dose doxazosin and torsemide are not recommended for the treatment of hypertension alone.