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慢性汞中毒的患者,用巯基络合剂驱汞是公认的方法。汞或其他因素所致肾脏损伤可影响汞在肾脏的蓄积和由尿排出。本文研究了肾脏受损时,D-青霉胺、N-乙酰-D,L-青霉胺和2,3-二巯基丁二酸(DMSA)三种巯基络合剂清除汞以及增加由尿排汞的能力。对体重200±20 g的雄性大鼠进行前处理,即皮下注射铬酸钠20 mg/kg造成肾脏损伤。对照组注射生理盐水。实验组大鼠于前处理后的第三天腹腔注入HgCl_2 2.5μM/kg和第三天或第七天向腹腔注入汞-青霉胺络合物(2.5 μM/kg Hg+7.5 μM D-青霉胺/kg),所有的汞
In patients with chronic mercury poisoning, the use of mercapto-complexing agents is a well-accepted method. Kidney damage caused by mercury or other factors can affect the accumulation and release of mercury in the kidneys. In this paper, three mercapto-complexing agents, D-penicillamine, N-acetyl-D, L- penicillamine and 2,3-dimercaptosuccinic acid (DMSA) Mercury discharge capacity. Male rats weighing 200 ± 20 g were pretreated with a subcutaneous injection of sodium chromate 20 mg / kg to cause kidney damage. The control group was injected with saline. In the experimental group, HgCl 2 2.5 μM / kg was intraperitoneally injected on the third day after pretreatment and mercury-penicillamine complex (2.5 μM / kg Hg + 7.5 μM D-cyanine was injected into the peritoneal cavity on the third or seventh day Mycamine / kg), all of the mercury