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最近提出,宫内节育器(IUD)在田鼠的生物学作用可能包括自放IUD的子宫角释放前列腺素F_(2α)。从放IUD子宫角释放的这一溶黄体因子达到邻近卵巢并抑制黄体的正常生理活动。为证实此设想,作者试图通过本实验,确定是否阻断放IUD的子宫角与邻近卵巢间的连结,将允许卵巢正常活动。用60～75天的金黄色田鼠做实验。在观察三个规律的动情周期后,于第四个周期的动情期,向一侧子宫角的宫颈端放入一段长10～12毫米的丝线做为IUD。于放IUD后的下个动情期与雄鼠交配。妊娠第6天,将对侧卵巢及输卵管切除,同时结扎或隔开放IUD的子宫角与邻近卵巢之间的连结。一部
It has recently been suggested that the biological effects of intrauterine devices (IUDs) in voles may release prostaglandin F_ (2α) from the uterine horn of self-releasing IUDs. This factor of lutein released from the release of the uterine horn of the IUD reaches adjacent ovaries and inhibits the normal physiological activity of the luteal. To confirm this hypothesis, the authors attempted to determine whether blocking the ligation of the uterine horn of the IUD to the adjacent ovaries through this experiment would allow normal ovarian activity. Experiment with golden vole from 60 to 75 days. After observing the three regular estrous cycles, during the fourth cycle of estrus, a length of 10 to 12 mm of silk was inserted into the cervical end of the uterine horn on one side for IUD. Mating males after next IUD release. On the 6th day of gestation, the contralateral ovary and the fallopian tube are resected, and the ligation of the uterus between the IUD and the adjacent ovary is performed simultaneously or separately. One