β_3肾上腺素能受体(β_3AR)曾被称为“非典型”β肾上腺素能受体(βAR)。自1989年以来,对不同种属的β_3AR先后克隆成功,与经典的β_1AR和β_2AR相比,β_3AR主要分布于脂肪组织,参与脂肪组织的产热、脂肪分解、提高机体代谢率等效应,在体脂恒定调节中起重要作用。近年来对β_3AR的组织分布、分子结构、药学特性和β_3AR的调节,以及β_3AR基因多态性与某些代谢相关性疾病的关系等诸多方面,进行了广泛而深入的研究,现就这几方面综述如下。 The β_3 adrenergic receptor (β_3AR) has been called the “atypical” β adrenergic receptor (βAR). Since 1989, β_3AR has been successfully cloned from different species. Compared with the classical β_1AR and β_2AR, β_3AR is mainly distributed in adipose tissue, which is involved in the production of fat tissue, lipolysis and metabolism. In vivo Constant lipid regulation plays an important role. In recent years, the organization and distribution of β 3AR, molecular structure, pharmacological properties and β 3AR regulation, as well as β 3AR gene polymorphism and some metabolic-related diseases and many other aspects, conducted extensive and in-depth study, are these aspects Summarized as follows.