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目的探讨C肽在胰岛β细胞功能的评定中的意义。方法随机抽出46例糖尿病患者及30例正常对照人群,通过口服葡萄糖后C肽和胰岛素释放试验,采用全自动电化学发光免疫分析仪检测血清中C肽和胰岛素含量的动态变化,分析其与血糖、糖化血红蛋白及果糖胺等糖尿病相关指标的相关性。结果糖尿病病人口服葡萄糖2 h后C肽含量与正常对照组相比差异有统计学意义(P<0.05),而空腹C肽,空腹及2 h胰岛素含量与正常对照组相比差异无统计学意义。同时糖尿病病人血清2 h C肽含量与空腹血糖、糖化血红蛋白、果糖胺及空腹C肽和2 h胰岛素含量具有显著相关性(r=-0.357,r=-0.449,r=-0.309,r=0.546,r=0.313;P<0.05)。结论血清C肽尤其是2 h C肽含量在评价胰岛β细胞质量与功能等方面具有重要的临床意义。
Objective To investigate the significance of C-peptide in the assessment of pancreatic β-cell function. Methods 46 cases of diabetic patients and 30 normal control subjects were randomly selected. The dynamic change of serum C-peptide and insulin content was detected by automatic chemiluminescence immunoassay after C-peptide and insulin release test of oral glucose. , Glycosylated hemoglobin and fructosamine and other related indicators of diabetes. Results Compared with the normal control group, the content of C-peptide in diabetic patients after oral glucose administration for 2 hours was significantly different (P <0.05), while the fasting C-peptide, fasting and 2-hour insulin contents were not significantly different from those in the normal control group . At the same time, the content of serum 2-h C peptide in diabetic patients was significantly correlated with fasting blood glucose, glycosylated hemoglobin, fructosamine, fasting C-peptide and insulin content at 2 h (r = -0.357, r = -0.449, r = -0.309, r = 0.546 , r = 0.313; P <0.05). Conclusion Serum C-peptide, especially 2-h C peptide, has important clinical significance in evaluating the quality and function of islet β-cell.