Raman scattering experiments for nominally pure and uranium doped CaF2 single crystals were presented. In all crystals, the Raman active T2g vibration mode of CaF2 was observed, whose frequency shift and full-width at half-maximum (FWHM) broadening correspond well with defects and impurities in CaF2 lattice. Additional Raman peaks develop in nominally pure CaF2 with high etch pits density and U6+:CaF2 crystals. Part of additional Raman peaks in the experimental results, which are assumed due to vibration modes from F- interstitials and vacancies, are in well agreement with the theoretical predications by employing the Green-function formulation. Raman scattering experiments for nominally pure and uranium doped CaF2 single crystals were presented. In all crystals, the Raman active T2g vibration mode of CaF2 was observed, whose frequency shift and full-width at half-maximum (FWHM) broadening correspond well with defects and and impurities in CaF2 lattice. Additional Raman peaks in nominally pure CaF2 with high etch pits density and U6 +: CaF2 crystals. Part of additional Raman peaks in the experimental results, which are assumed due to vibration modes from F-interstitials and vacancies, are in well agreement with the theoretical predications by employing the Green-function formulation.