石棉能引起石棉肺、肺纤维化和肺癌等肺部疾病,但其机制尚未完全阐明。越来越多的研究表明,暴露于石棉等伤害性刺激之后,肺上皮细胞凋亡是其引发肺部疾病并导致病情进一步发展的重要因素。本文即以石棉引起肺上皮细胞凋亡过程中,活性氧的产生、DNA损伤、线粒体和p53基因等致凋亡机制的研究进展做一综述。 Asbestos can cause lung diseases such as asbestosis, pulmonary fibrosis and lung cancer, but its mechanism has not been fully elucidated. More and more researches have shown that the apoptosis of lung epithelial cells after exposing to noxious stimuli such as asbestos is an important factor in inducing pulmonary diseases and leading to the further development of the disease. This article reviews the progress of the research on the mechanism of apoptosis induced by asbestos-induced lung epithelial cells such as reactive oxygen species, DNA damage, mitochondria and p53 gene.