氯氮平(colozapine)抗精神病作用疗效显著,临床应用愈来愈普遍,使用频率逐渐上升到第1位。但其所致的副作用往往影响治疗,其中以流涎最常见,发生率43.1％～93.4％。而且与服药时间无关。氯氮平所致流涎的机制尚不清楚,亦无特效治疗。笔者用扑尔敏、息斯敏治疗,报道如下。 The effect of anti-psychosis of colozapine is remarkable. The clinical application is more and more common, and the frequency of use gradually increases to No. 1. However, its side effects often affect the treatment, of which the most common salivation, the incidence of 43.1% to 93.4%. And has nothing to do with medication time. Clozapine-induced salivation mechanism is unclear, there is no effective treatment. I use chlorpheniramine, astemizine treatment, reported below.