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实验发现F30385是一个兼具明显杀日本血吸虫童虫与成虫的硝基呋喃丙烯酰胺类的口服药物。小白鼠一次口服F30385的半数致死置为979±98毫克/公斤(P=0.95)。小白鼠感染尾蚴后4-11天,一次口服F30385 11.4毫克/鼠,减虫率高达90-99％,显著比对32天成虫的杀虫作用强。按等毒性剂量用F30385及F30066治疗小白鼠与兔血吸虫病的结果,F30385的疗效比F30066高。7只感染血吸虫病的犬用总剂量为700毫克/公斤的7-14天疗法治疗后,减虫率为95％。动物口服F30385后的毒性反应主要为胃肠道刺激与肾和肝的受损。小白鼠病理观察结果认为,停药后病变均渐恢复。
The experiment found that F30385 is an oral medicine that obviously kill nitrofurans acrylamide of schistosomula and adult worms. The median lethal dose of oral administration of F30385 in mice was 979 ± 98 mg / kg (P = 0.95). After mice were infected with cercariae 4 to 11 days after oral administration of F30385 11.4 mg / mouse, the worm reduction rate was as high as 90-99%, significantly stronger than the 32-day adult insecticidal effect. F30385 and F30066 treatment of mice and rabbits with schistosomiasis results at equal toxicity dose, F30385 higher efficacy than F30066. Seven dogs infected with schistosomiasis had a worm reduction rate of 95% after 7-14 days of treatment at a total dose of 700 mg / kg. Toxicity of animals after oral administration of F30385 mainly gastrointestinal irritation and kidney and liver damage. Pathological observation of mice that the pathological changes are gradually recovered.