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目的：观察雌二醇对去卵巢大鼠血清一氧化氮的影响。方法：采用去卵巢大鼠模型，通过肌注苯甲酸雌二醇2周，测量不同雌激素状态下大鼠血清一氧化氮（NO）的浓度，用镉还原法测NO2／NO3的量来反映NO浓度。结果：切除卵巢三周后，血浆雌二醇浓度显著下降（P＜0，05），NO浓度轻度下降，但无统计学差异（P＞0．05），当补充大剂量雌二醇后，发现去卵巢大鼠血清NO显著升高（P＜0．05），血清E2水平也极显著升高（P＜0．01）。结论：雌二醇可促进去卵巢大鼠血清NO水平增加，这可能是雌激素抑制动脉粥样硬化和降低女性绝经后冠心病发病危险的重要机制之一。
Objective: To observe the effect of estradiol on serum nitric oxide in ovariectomized rats. Methods: The ovariectomized estradiol was intramuscularly injected for 2 weeks in ovariectomized rats model to measure the concentration of nitric oxide (NO) in rats under different estrogen status, and the content of NO2 / NO3 was measured by cadmium reduction NO concentration. Results: After 3 weeks of ovariectomy, the plasma estradiol concentration decreased significantly (P <0,05), NO concentration decreased slightly, but no significant difference (P> 0.05). After ovariectomized with high dose of estradiol (P <0.05). The level of serum E2 was also significantly increased (P <0.01). Conclusion: Estradiol can promote the serum NO level of ovariectomized rats, which may be one of the important mechanisms of estrogen inhibiting atherosclerosis and reducing the risk of coronary heart disease in women.