以胞嘧啶脱氨酶基因为主的自杀基因治疗已日渐引起肿瘤研究者的兴趣 ,近几年出现的基因联合放疗对恶性肿瘤的治疗 ,使两者之间的优势得以互补 ,大大增强了对肿瘤治疗的效果。本文就胞嘧啶脱氨酶基因联合放疗对恶性肿瘤治疗的作用机制、基因转导方法、靶向性表达、基因显像、治疗效果等方面予以综述。 Suicide gene therapy based on cytosine deaminase gene has increasingly attracted the interest of tumor researchers. The combination of gene therapy and radiation therapy in recent years has provided complementary treatment to malignant tumors, greatly enhancing the The effect of cancer treatment. This article reviews the mechanism of action of cytosine deaminase gene combined with radiotherapy on the treatment of malignant tumors, gene transduction methods, targeted expression, gene imaging, and therapeutic effects.