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本文介绍猴子输注Ⅱ号氟碳代血液(FCBS,即FCE)的效应。成年两性猴13只,体重3.0～7.75kg。实验组8只,输注Ⅱ号氟碳代血液30m1/kg,对照组5只,输注等量的低分子右旋糖酐。输注Ⅱ号氟碳代血液后,心博出量、PaO_2增加,且比对照组更为明显。血像、血清电解质和凝血功能未见明显改变,纤溶活性、SGOT、SGPT有一过性升高,但与对照组比未见明显差别。大体解剖可见肝脾肿大。镜检见部分肝脏的枯否氏细胞和脾脏红髓的网状细胞星泡沫状。直到输注后120天,尽管泡沫细胞数量已有减少,但仍可观察到该现象。结果提示猴子一次输注30ml/kgⅡ号氟碳代血液是安全的,可作为临床应用的参考。对输注氟碳代血液后的类过敏样反应和远期效应有必要作更深入的研究。
This article describes the effect of monkey transfusion with fluorocarbon substitution II (FCBS). 13 adult males, weighing 3.0 ~ 7.75kg. Experimental group 8, infusion of fluorocarbon Ⅱ Ⅱ blood 30m1 / kg, control group of 5, the same amount of infusion of low molecular weight dextran. Infusion of fluorocarbon Ⅱ blood, cardiac output, PaO_2 increased, and more obvious than the control group. Serum, serum electrolytes and coagulation did not change significantly, fibrinolytic activity, SGOT, SGPT transiently increased, but no significant difference compared with the control group. Gross anatomy of the liver and spleen can be seen. Microscopic examination of some of the liver’s dry cells and spleen red pulp of the reticular cell star foam. Until 120 days after infusion, this phenomenon can be observed despite a reduction in the number of foam cells. The results suggest that once the monkey infusion of 30ml / kg Fluorocarbon blood is safe, can be used as a reference for clinical applications. After the infusion of fluorocarbon blood-class allergic-like response and long-term effects of the need for more in-depth study.