近年来人群研究显示，神经心理行为功 能试验为目前检测锰早期神经毒性的一种较好手段。值得注意的是，实验性锰中毒会引起肝病变，人慢性肝病也可以继发锰中毒。动物实验表明，锰可以引起心脏收缩功能降低和低血压，脱离接触可以很快逆转；生殖毒性则表现为母体毒性（进食量和妊娠子宫体重降低等）和胎儿毒性（平均体重减少、晚期吸收数增加和骨骼畸形）。然而，职业人群的锰肝、血管、生殖与发育毒性研究甚少或空白，有待进一步探讨 In recent years, population studies have shown that neuropsychological behavioral tests for the current detection of early neurotoxicity of manganese is a better means. It is noteworthy that, experimental manganese poisoning can cause liver disease, human chronic liver disease can also be secondary to manganese poisoning. Animal experiments show that manganese can cause decreased cardiac systolic function and hypotension, disengagement can be quickly reversed; reproductive toxicity showed maternal toxicity (food intake and pregnancy uterine weight loss, etc.) and fetal toxicity (average weight loss, late absorption Increase and skeletal deformity). However, there is little or no research on manganese liver, blood vessel, reproductive and developmental toxicity in occupational groups, which needs to be further explored