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药物导致胃肠道损害占全部药物不良反应发生率的20％～40％,药物可通过改变胃肠粘膜上皮细胞的结构或影响肠运动,刺激或抑制消化腺分泌或者中和胃酸,并影响胃肠的血流和淋巴流而导致胃肠道损害。常见对胃肠道有损害的药物主要有以下几类: 一、解热消炎镇痛药 阿司匹林具有解热、镇痛、抗炎、抗风湿,小剂量具有抑制血小板聚集的作用。胃肠道反应可引起恶心、呕吐、腹痛,长期应用可诱发和加重消化性溃疡,甚至引起出血或穿孔。
Drugs cause gastrointestinal damage accounted for 20% to 40% of all adverse drug reactions, the drug can change the structure of gastrointestinal mucosa epithelial cells or affect intestinal motility, stimulate or inhibit the secretion of the digestive gland or stomach acid and affect the stomach Intestinal blood flow and lymphatic flow lead to gastrointestinal damage. Common damage to the gastrointestinal tract drugs mainly in the following categories: First, antipyretic analgesic Aspirin with antipyretic, analgesic, anti-inflammatory, anti-rheumatoid, low-dose inhibition of platelet aggregation. Gastrointestinal reactions can cause nausea, vomiting, abdominal pain, long-term use can induce and aggravate peptic ulcer, and even cause bleeding or perforation.