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Metastasizing cancer cells can invade the extracellular matrix using surface motor organelles,termed invadopodia that contact and dissolvethe matrix.Various membrane-bound proteases and their associated proteins such as integrins localized on the invadopodial membranes are re-sponsible for the extracellular matrix degradation and cell invasion,A control mechanism of cancer invasion and metastasis may involve the for-mation of such invadopodial protease assembly(IPA),induction of IPA,and the regulation of invasion by a novel immune complex in senum.
Metastasizing cancer cells can invade the extracellular matrix using surface motor organelles, termed invadopodia that contact and dissolve the matrix.Various membrane-bound proteases and their associated proteins such as integrins localized on the invadopodial membranes are re-sponsible for the extracellular matrix degradation and cell invasion ,A control mechanism of cancer invasion and metastasis may involve the for-mation of such invadopodial protease assembly(IPA), induction of IPA, and the regulation of invasion by a novel immune complex in senum.