目的分析奥沙利铂联合氟尿嘧啶与替吉奥治疗晚期胃癌的临床疗效。方法选取46例晚期胃癌患者,随机分为对照组与观察组,各23例。对照组采用叶酸钙、奥沙利铂以及氟尿嘧啶治疗,观察组采用奥沙利铂联合替吉奥治疗,对比两组临床效果与不良反应。结果观察组有效率为91.30%,对照组为65.22%,观察组明显优于对照组(P<0.05)。观察组红细胞减少、血小板减少、呕吐恶心、贫血、周围神经毒性以及口腔黏膜等不良反应发生率明显低于对照组(P<0.05)。结论对于晚期胃癌患者采用奥沙利铂联合替吉奥治疗,效果明显,不易发生不良反应,安全可靠,具有临床应用价值。 Objective To analyze the clinical efficacy of oxaliplatin combined with 5-fluorouracil and tegaserod in the treatment of advanced gastric cancer. Methods Forty-six patients with advanced gastric cancer were randomly divided into control group and observation group, with 23 cases in each group. The control group was treated with calcium folate, oxaliplatin and fluorouracil. The observation group was treated with oxaliplatin combined with tirofiban, and the clinical effects and adverse reactions were compared between the two groups. Results The effective rate was 91.30% in the observation group and 65.22% in the control group, which was significantly better in the observation group than in the control group (P <0.05). The incidence of erythrocyte reduction, thrombocytopenia, vomiting nausea, anemia, peripheral neurotoxicity and oral mucosal adverse reactions in observation group were significantly lower than those in control group (P <0.05). Conclusion The treatment of advanced gastric cancer patients with oxaliplatin combined with tigiao, the effect is obvious, not prone to adverse reactions, safe and reliable, with clinical value.