论文部分内容阅读
为探讨格林—巴利综合征(GBS)患者血浆TNF-α变化及其意义。应用ELISA双抗体夹心法,检测36例住院治疗的GBS患者血浆肿瘤坏死因子-α(TNF-α)浓度。结果发现GBS患者血浆TNF-α浓度明显高于对照组(P<0.001),且与临床分型显著相关(P<0.05)。19例接受糖皮质激素治疗,病情好转的患者恢复期血浆TNF-α浓度相应下降至接近正常。结论:血浆TNF-α可能通过直接和间接效应参与脱髓鞘的病理损害,在GBS的发病机制中起重要作用,检测血浆TNF-α浓度对估测预后有一定意义。
To investigate the changes of plasma TNF-αin patients with Guillain-Barre Syndrome (GBS) and its significance. Plasma concentrations of tumor necrosis factor-α (TNF-α) in 36 hospitalized patients with GBS were detected by ELISA double antibody sandwich method. The results showed that the concentration of TNF-α in plasma of GBS patients was significantly higher than that of the control group (P <0.001), and was significantly correlated with clinical classification (P <0.05). 19 patients receiving glucocorticoid therapy, convalescent patients with convalescent plasma TNF-α concentration decreased to near normal. CONCLUSION: Plasma TNF-α may play an important role in pathogenesis of GBS through direct and indirect effects. Detection of plasma TNF-α concentration may have some significance in estimating prognosis.