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为了探讨偏头痛与Ｐ物质（ＳＰ）、神经激肽Ａ（ＮＫＡ）含量之间的关系，本研究应用放射免疫法测定了６９例无先兆性偏头痛患者组与３１例正常对照组血浆ＳＰ与ＮＫＡ含量，结果发现ＳＰ与ＮＫＡ在偏头痛患者组较正常对照组升高，且偏头痛发作期该两种神经肽较间歇期更高。提示ＳＰ与ＮＫＡ可能通过降低痛阈等机理参予偏头痛的发作。本组男女患者间ＳＰ与ＮＫＡ含量无明显差异，而临床上偏头痛多见于女性，常于月经期发病，提示ＳＰ、ＮＫＡ等虽参予其发病，但性激素变化在男女发病率不同方面可能起较重要作用。
In order to investigate the relationship between migraine and substance P (SP) and neurokinin A (NKA) content, we used radioimmunoassay to determine the relationship between migraine headache and 31 normal controls NKA levels. The results showed that SP and NKA increased in migraine patients compared with normal control group, and the two neuropeptides were higher than intermittent during migraine attack. Tip SP and NKA may participate in migraine attacks by reducing the mechanism of pain and other mechanisms. The group of male and female patients SP and NKA content was no significant difference, and clinically migraine more common in women, often in the menstrual period, suggesting that SP, NKA, although its participation in the incidence, but the sex hormone changes in different aspects of the incidence of men and women may More important role.