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本文对骨巨细胞瘤(GCT)的传统组织学分级与其生物行为不甚相符的原因进行了研究。51例 GCT为研究组,13例骨囊肿(良性)和15例骨肉瘤(恶性)为对照组,以图像分析仪(IAT)对细胞核(GCT 取基质细胞核),进行了体视学形态计量研究(8项参量),DNA 定量研究,DNA 倍体类型研究,术后复发病例的 DNA 倍性与其传统分级的比较研究。上述四个方面的结果经统计学处理发现 GCT Ⅰ级和Ⅱ级之间无显著差别,且它们的生物学属性在潜在恶性和低度恶性范畴。研究还揭示 GCT 的 DNA≥5C 细胞数超过7%为术后复发、转移的高危病例。
In this paper, the traditional histological grade of giant cell tumor of bone (GCT) has not been consistent with its biological behavior. Fifty-one patients with GCT as the study group, 13 with bone cysts (benign) and 15 with osteosarcoma (malignant) as the control group. The morphological measurement of the nucleus (GCT with stromal nuclei) was performed with an image analyzer (IAT). (8 parameters), DNA quantification, DNA ploidy type, post-operative recurrences, DNA ploidy and its traditional grading. The results of the above four aspects were statistically processed and found no significant difference between GCT grade I and grade II, and their biological properties were in the category of potentially malignant and low malignant. The study also revealed that GCT with more than 7% of DNA ≥ 5C cells was a high-risk case of postoperative recurrence and metastasis.