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４５例白血病患者，采用固相放射免疫分析法（ＲＩＡ）测定其血清白细胞介素２（ＩＬ－２）的水平，以流式细胞仪（ＦＣＭ）检测其外周血单个核细胞（ＰＭＮＣ）上膜白细胞介素２受体（ｍＩＬ－２Ｒ）的表达，用双抗体夹心ＣＥＬＩＳＡ法测定其血清肿瘤坏死固子α（ＴＮＦ－α）的含量。发现急性白血病（ＡＬ）及慢性位细胞白血病原始细胞危象（ＣＭＬ－ＢＣ）患者血清ＩＬ－２和ＴＮＦ－α的水平明显高于正常，ＣＭＬ－ＢＣ尤其急淋变者的ＰＭＮＣ上ｍＩＬ－２Ｒ阳性率较高，并与血清ＴＮＦ－α有关，而与血清ＩＬ－２无关，ｍＩＬ－２Ｒ阳性常提示白血病患者疗效差，预后不良。
In 45 leukemia patients, serum interleukin-2 (IL-2) levels were measured by solid-phase radioimmunoassay (RIA), and peripheral blood mononuclear cells (PMNC) were examined by flow cytometry (FCM). The expression of interleukin 2 receptor (mIL-2R) was determined by measuring the level of tumor necrosis TNF-α in serum by double antibody sandwich CELISA. The levels of serum IL-2 and TNF-α in patients with acute leukemia (AL) and chronic myelogenous leukemia blast crisis (CML-BC) were found to be significantly higher than those of normal, and those of PMLC on mLC-2R of CML-BC were particularly acute. The positive rate is high, and it is related to serum TNF-α, while it is not related to serum IL-2. Positive mIL-2R often indicates poor efficacy and poor prognosis in patients with leukemia.