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目的:观察盐酸格拉司琼(granisetronhydrochloride)预防抗癌药(铂类、非铂类)引起的恶心和呕吐的疗效。方法:将接受化学治疗的恶性肿瘤患者65例随机分成A、B两组:A组(顺铂组)32例,用含顺铂(顺式-二氨二氯,cis-daminedichloro-platinum,cisplatin,DDP)的方案进行化学治疗,B组(非顺铂组)33例,用不含顺铂的方案进行化学治疗,两组于化学治疗前分别予国产盐酸格拉司琼或进口盐酸格拉司琼30mg注射液预防恶心、呕吐。比较两者对预防化学治疗药引起的恶心、呕吐的效果。结果:A、B组24小时恶心发生率分别为69%、48%,呕吐控制率分别为81%、97%,两者差异无统计学意义(P>0.05)。结论:盐酸格拉司琼具有良好的防治化学治疗药引起的恶心、呕吐的作用。
Objective: To observe the efficacy of granisetron hydrochloride in preventing nausea and vomiting caused by anticancer drugs (platinum and non-platinum). Methods: Sixty-five patients with malignant tumor undergoing chemotherapy were randomly divided into two groups: group A (cisplatin group), 32 cases with cisplatin (cis-dihydrochloride, cisplatin , DDP) regimen, 33 patients in group B (non-cisplatin group) received chemotherapy with cisplatin-free regimen, and received either granisetron hydrochloride or granisetron hydrochloride 30mg injection to prevent nausea and vomiting. Compare the effects of both on preventing nausea and vomiting caused by chemotherapeutic drugs. Results: The incidences of nausea at 24 hours in groups A and B were 69% and 48%, respectively. The rates of vomiting were 81% and 97%, respectively. There was no significant difference between the two groups (P> 0.05). Conclusion: Granisetron hydrochloride has a good effect of preventing and treating nausea and vomiting caused by chemotherapy drugs.