论文部分内容阅读
目的：探讨心肌顿抑发生后血流动力学和血小板聚集率的变化，以及钙通道拮抗剂呋喃丙吡啶对心肌顿抑兔的保护作用。方法：经冠状动脉结扎法建立兔心肌顿抑模型。用药组缺血前用呋喃丙吡啶静脉给药。结果：对照组再灌注后１５ｍｉｎ血浆最大血小板聚集率达高峰（６１．７６％±９．２２％），用药组同一时间点血浆最大血小板聚集率较对照组低（４０．２３％±５．３９％，Ｐ＜０．０１）。对照组血压较缺血前明显下降（Ｐ＜０．０５），用药组：Ⅰ组（１ｍｇ·ｋｇ－１）血压变化与对照组无统计学差异，Ⅱ组（３ｍｇ·ｋｇ－１）缺血后舒张压下降明显与对照组相比差异显著，随着再灌注时间延长舒张压逐步回升。结论：心肌顿抑发生后伴有血流动力学变化及血小板聚集率增高，缺血前静脉应用呋喃丙吡啶治疗对心肌损伤具有保护作用。
OBJECTIVE: To investigate the changes of hemodynamics and platelet aggregation after myocardial stunning, and the protective effect of furanopyopyridine, a calcium channel antagonist, on myocardial stunning in rabbits. Methods: Rabbit myocardial stunning model was established by coronary artery ligation. The medication group was given iv furanopyridine intravenously before ischemia. Results: In the control group, the maximum plasma platelet aggregation rate (61.76% ± 9.22%) reached its peak 15 min after reperfusion. The maximum plasma platelet aggregation rate of the control group was lower than that of the control group at the same time point (40.23% ± 5.39 %, P <0.01). Compared with the control group, the blood pressure in the control group decreased significantly (P <0.05). There was no significant difference in the blood pressure between the control group and the control group (1 mg · kg-1) After diastolic blood pressure decreased significantly compared with the control group significant difference, with the reperfusion time prolonged diastolic blood pressure gradually rise. CONCLUSION: Myocardial stunned rats are associated with hemodynamic changes and platelet aggregation rate. Pretreatment with furanylpyridine may have a protective effect on myocardial injury.