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目的探讨直视下新型引导式实验动物插管装置及改良术在家兔肝动脉插管术中应用的可行性。方法将45只白家兔随机均分为3组,组Ⅰ在剖腹直视下用常规插管装置经肝总动脉按常规法行肝动脉插管术,组Ⅱ在DSA监视下经股动脉按Seldinger穿刺法行肝动脉插管术,组Ⅲ在剖腹直视下用新型引导式插管装置经胃十二指肠动脉采取改良术式逆行肝动脉插管术。对3组家兔肝动脉插管的成功率、插管时间及术后效果进行比较和评价。结果组Ⅰ、Ⅱ、Ⅲ家兔肝动脉插管术的成功率分别为60.0%、73.3%、86.7%,组Ⅲ与组Ⅰ相比差异有统计学意义(P<0.05);所用时间分别为(42.0±0.5)、(31.4±0.8)、(25.2±0.6)min,组Ⅲ与组Ⅰ和组Ⅱ相比差异具有统计学意义(P<0.01,P<0.05);术后不良反应及并发症的发生率分别为46.7%、33.3%、20.0%,组Ⅲ与组Ⅰ和组Ⅱ相比差异具有统计学意义(P<0.01,P<0.05)。结论在剖腹直视下,用新型引导式插管装置经胃十二指肠动脉行改良术式逆行肝动脉插管术提高了实验家兔肝动脉插管的质量和效率,具有安全、简便等优点,对临床具有一定参考价值。
Objective To investigate the feasibility of a new guided experimental animal intubation device under direct vision and improved technique in hepatic artery cannulation in rabbits. Methods 45 white rabbits were randomly divided into three groups. Group Ⅰ underwent conventional hepatic artery cannulation by conventional hepatic artery under cesarean section under general anesthesia. Group Ⅱ underwent hepatectomy via DSA Seldinger puncture hepatic artery catheterization, group Ⅲ under cesarean section with a new type of guided intubation device through the gastro-duodenal artery to take modified surgical retrograde hepatic artery catheterization. The success rate of hepatic artery intubation, intubation time and postoperative effects of three groups of rabbits were compared and evaluated. Results The success rates of hepatic artery cannulation were 60.0%, 73.3% and 86.7% in group Ⅰ, Ⅱ and Ⅲ respectively. The difference between group Ⅲ and group Ⅰ was statistically significant (P <0.05) (42.0 ± 0.5), (31.4 ± 0.8) and (25.2 ± 0.6) min respectively. The difference between group Ⅲ and group Ⅰ and group Ⅱ was statistically significant (P0.01, P0.05). The postoperative adverse reactions and complications The incidence of disease was 46.7%, 33.3% and 20.0% respectively. The difference between group Ⅲ and group Ⅰ and group Ⅱ was statistically significant (P <0.01, P <0.05). Conclusion Under the laparotomy, the improved guiding hepatic artery cannulation can improve the quality and efficiency of hepatic arterial cannulation in rabbits with a new type of guided intubation via transgastric duodenal artery. It is safe and easy to use Advantages, has a certain reference value for clinical.