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为了确定在非洲儿童中扩大疫苗接种规划时能否包括乙型肝炎(HB)疫苗,作者用实验动物研究了HB疫苗与BCG、DTP-脊髓灰质炎疫苗(DTPP)、DTP、麻疹和黄热病疫苗联合应用的相互影响。将豚鼠或小鼠随机分成3组:第1组为试验组,同时注射HB疫苗和上述任何一种疫苗;第2组为阳性对照组,单独注射HB疫苗或其它某种疫苗;第3组为阴性对照组,仅注射生理盐水。HB疫苗不含佐剂,皮下注射。用RIA测定抗-HBs;按欧洲药典介绍的方法测定白喉和破伤风抗
To determine whether hepatitis B vaccine can be included in expanding vaccination programs among African children, the authors studied HB vaccine with BCG, DTP-polio vaccine (DTPP), DTP, measles and yellow fever using experimental animals Interactions of vaccines. The guinea pigs or mice were randomly divided into 3 groups: the first group was the experimental group with HB vaccine and any one of the above vaccines; the second group was the positive control group, the HB vaccine alone or some other vaccine; the third group was Negative control group, only saline injection. HB vaccine does not contain adjuvant, subcutaneous injection. Determination of anti-HBs by RIA; determination of diphtheria and tetanus by the method described in the European Pharmacopoeia