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家兔出血性休克或中毒性休克引起的低血压,均能被侧脑室内注入纳洛酮、酚妥拉明或肉桂硫胺所逆转。当中枢同时注入纳洛酮和酚妥拉明、纳洛酮和肉桂硫胺或酚妥拉明和肉桂硫胺后,作用强度不变,血压逆转的时间明显缩短,达到峰值时间也明显缩短。当中枢分别注入去甲肾上腺素、吗啡或5—羟色胺,使血压下降,可分别被纳洛酮或肉桂硫胺、酚妥拉明或肉桂硫胺、酚妥拉明或纳洛酮所逆转。提示:休克兔低血压的中枢反应原可能是多个,这些反应原最终都作用在同一个作用点上。这一共同作用点对上述三种阻断剂均敏感,它们的作用强度不能总和,但作用时间可以总和。
Hemorrhagic shock in rabbits or hypotension induced by toxic shock can be reversed by intracerebroventricular injection of naloxone, phentolamine or cinnamic acid. When the central injection of naloxone and phentolamine, naloxone and cinnamamine thiamine or phentolamine and cinnamamine thiamine, the same intensity, blood pressure reversal time was significantly reduced to peak time was significantly shortened. When norepinephrine, morphine, or serotonin were infused into the center, respectively, the blood pressure was decreased, which was reversed by naloxone or cinnamic acid thiamine, phentolamine or cinnamyl thiamine, phentolamine or naloxone, respectively. Tip: shock rabbit hypotensive central reaction may be multiple, these reactants eventually act on the same point of action. This common point of action is sensitive to all three of the above blockers, their intensity of action can not be combined, but the duration of action can be combined.