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目的分析新疆维吾尔族儿童脑瘫发生的危险因素,为脑瘫的预防和治疗提供临床依据。方法收集2013年1月-2015年6月新疆自治区人民医院收治的0~6岁维吾尔族脑瘫患儿286例,与相同年龄段的维吾尔族健康儿童572名作比较,应用单因素和多因素Logistic回归分析脑瘫发生的危险因素。结果单因素Logistic分析显示:影响脑瘫发生涉及遗传因素、产前、产时和产后的多种因素。多因素Logistic回归分析得出该种族儿童脑瘫的危险因素主要有近亲结婚、脑病家族史、母孕期感染、母不良孕产史、胎龄<32周、宫内窘迫、低出生体重、新生儿窒息、新生儿重度黄疸、新生儿缺氧缺血性脑病。结论新疆维吾尔族儿童脑瘫的发生涉及多种危险因素,应积极加强对各危险因素的预防和干预工作,以降低儿童脑瘫的发生率。
Objective To analyze the risk factors of cerebral palsy in Xinjiang Uygur children and provide the clinical evidence for the prevention and treatment of cerebral palsy. Methods A total of 286 children aged 0-6 years with Uygur cerebral palsy who were admitted to People’s Hospital of Xinjiang Uygur Autonomous Region from January 2013 to June 2015 were compared with 572 healthy Uyghur children of the same age group and were analyzed by single factor and multivariate Logistic regression Analysis of risk factors for cerebral palsy. Results Single-factor Logistic analysis showed that the factors affecting cerebral palsy involved in genetic factors, prenatal, postpartum and postpartum a variety of factors. Multivariate Logistic regression analysis showed that the risk factors of cerebral palsy in this racial group were the following: cousin marriage, family history of encephalopathy, maternal infection, maternal history of poor pregnancy, gestational age <32 weeks, intrauterine distress, low birth weight, neonatal asphyxia , Severe neonatal jaundice, neonatal hypoxic-ischemic encephalopathy. Conclusion The occurrence of cerebral palsy in Xinjiang Uygur children involves many risk factors. Prevention and intervention of various risk factors should be strengthened to reduce the incidence of cerebral palsy in children.