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目的研究猪再生肝肝细胞生长因子 (PRHGF)对急性肝衰竭的治疗作用。方法采用硫代乙酰胺 (TAA)灌胃造成大鼠急性肝衰竭 ,PRHGF腹腔给药 ,观察其治疗作用。结果PRHGF能显著提高急性肝衰竭大鼠存活率 ,降低肝衰竭大鼠血清总胆红素含量、丙氨酸转移酶活性及肿瘤坏死因子的含量 ,与模型组比较差异显著 (P <0 .0 5 ) ;并能明显减少肝细胞坏死 ,促进肝细胞再生。结论PRHGF对TAA所致大鼠急性肝衰竭具有显著的治疗作用
Objective To study the therapeutic effect of porcine reproductive liver hepatocyte growth factor (PRHGF) on acute liver failure. Methods Acute hepatic failure and PRHGF intraperitoneal injection were induced by intragastric administration of thioacetamide (TAA), and the therapeutic effect was observed. Results PRHGF can significantly improve the survival rate of rats with acute liver failure, reduce serum total bilirubin, alanine aminotransferase activity and tumor necrosis factor levels in rats with liver failure, the difference was significant (P <0. 0 5); and can significantly reduce liver cell necrosis and promote liver cell regeneration. Conclusion PRHGF has a significant therapeutic effect on TAA-induced acute liver failure in rats