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目的探讨妇科肿瘤患者应用凝血指标的临床价值。方法选取天津市中心妇产科医院2014年7月-2015年7月收治的卵巢恶性肿瘤26例、子宫颈恶性肿瘤115例以及子宫内膜恶性肿瘤55例,共196例为妇科恶性肿瘤组;另选取同期健康体检者200例为对照组。采用全自动血凝分析仪SYXMEX CA-7000对妇科恶性肿瘤患者的D-二聚体(D-dimer)、纤维蛋白原(FIB)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)以及凝血酶时间(TT)予以检测。结果妇科恶性肿瘤患者FIB与D-dimer水平较正常对照组增高,差异有统计学意义(P<0.05);APTT、PT和TT水平与对照组相比差异无统计学意义(P>0.05)。其中卵巢癌、宫颈癌与子宫内膜癌患者D-dimer水平均高于正常对照组,差异具有统计学意义(P<0.05)。结论 FIB、D-二聚体水平对妇科恶性肿瘤的实验室检查有重要意义。
Objective To investigate the clinical value of coagulation index in gynecologic oncology patients. Methods Twenty-six cases of ovarian cancer, 115 cases of cervical cancer and 55 cases of endometrial cancer were treated in Tianjin Obstetrics and Gynecology Hospital from July 2014 to July 2015. A total of 196 cases were treated with gynecological malignant tumor. Another 200 healthy subjects were selected as the control group. D-dimer, fibrinogen (FIB), prothrombin time (PT), and activated partial thromboplastin time (hs-CRP) were measured in patients with gynecologic malignancies using the SYXMEX CA- APTT) and thrombin time (TT) to be detected. Results The levels of FIB and D-dimer in patients with gynecologic malignancy were significantly higher than those in the control group (P <0.05). There was no significant difference in APTT, PT and TT levels between the two groups (P> 0.05). The levels of D-dimer in patients with ovarian cancer, cervical cancer and endometrial cancer were higher than those in the normal control group, with statistical significance (P <0.05). Conclusion The levels of FIB and D-dimer are important for the laboratory examination of gynecologic malignancies.