Presently, there is a growing interest in herbal remedies. Neem (Azadirachta indica) has been used in traditional medicine over centuries. In the present study, the effects of water extracts of Azadirachta indica seeds, stems, flowers and bark on the changes of hemoglobin content (Hb) and glucose levels in the blood of Rattus norvegicus were investigated. Different doses of A. indica water extracts of seeds, stems, flowers and bark were injected to the tested animals every 48 h for 14 days. Significant decrease in both hemoglobin content and glucose levels in the blood samples in all groups of injected rats were compared to control group. However, in all groups higher decrease was shown in the rats injected with 1 g·mL-1 of A. indica water extracts. In addition, the present study showed no significant relationship between decreased hemoglobin content and glucose levels in blood samples, and increased doses injected. In conclusion, A. indica has the potential to decrease both hemoglobin content and blood glucose levels. Present the, there is a growing interest in herbal remedies. Neem (Azadirachta indica) has been used in traditional medicine over centuries. In the present study, the effects of water extracts of Azadirachta indica seeds, stems, flowers and bark on the changes of hemoglobin content (Hb) and glucose levels in the blood of Rattus norvegicus were investigated. Different doses of A. indica water extracts of seeds, stems, flowers and bark were injected to the tested animals every 48 h for 14 days. Significant decrease in both hemoglobin content and glucose levels in the blood samples in all groups of injected rats were compared to control group. However, in all groups higher increase was shown in the rats injected with 1 g · mL-1 of A. indica water extracts. the present study showed no significant relationship between decreased hemoglobin content and glucose levels in blood samples, and increased doses injected. In conclusion, A. indica has the potential to decrease both hemoglobi n content and blood glucose levels.