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目的:通过观察痰热清注射液对肺癌支气管动脉化疗灌注术后中医证候、不良反应等指标的前后对比,探讨痰热清注射液对肺癌支气管动脉化疗灌注术后的辅助作用。方法:本课题采用随机、对照的研究方法,将符合标准的40例肺癌患者随机分为治疗组和对照组,每组20例,治疗组:介入治疗+中药痰热清注射液,痰热清注射液每日1次30mL静脉滴注,1周为1个疗程,术后给予西医常规对症处理。对照组:单纯介入治疗,术后给予西医常规对症处理,两组患者均行支气管动脉化疗灌注术:化疗药物为卡铂0.2g(或顺铂80mg)、CTX0.6g和THP40mg。采用改良式Seldiner技术,行选择性和超选择性支气管动脉插管,经导管缓慢注入化疗药物。记录两组患者术前、术Ridit检验方法,用SPSS13.0统计软件进行分析。结果:术后治疗组中医证候、疗效总有效率、不良反应发生率等观察指标,较对照组均有较明显的提高。结论:中药痰热清注射液作为肺癌介入化疗的辅助用药,能有效改善术后发热等中医证候,减轻化疗的毒副作用,提高患者的生存质量,具有独特的优势,值得进一步研究并在临床推广应用。
OBJECTIVE: To observe the effect of Tanreqing Injection on the indexes of traditional Chinese medicine (TCM) and adverse reactions after bronchial artery infusion chemotherapy in patients with lung cancer and to explore the auxiliary effect of Tanreqing injection on the bronchial artery after lung perfusion chemotherapy. Methods: A randomized, controlled study was conducted in this study. Forty lung cancer patients who met the criteria were randomly divided into treatment group and control group, with 20 cases in each group. The treatment group included interventional therapy + Tanreqing Injection and Tanreqing Injection once daily 30mL intravenous infusion, 1 week for a course of treatment, after giving Western conventional symptomatic treatment. Control group: simple interventional therapy, western medicine conventional symptomatic treatment after surgery, two groups of patients underwent bronchial artery infusion chemotherapy: carboplatin 0.2g (or cisplatin 80mg), CTX0.6g and THP40mg. Adopt modified Seldiner technology, selective and super selective bronchial artery cannulation, slow infusion of chemotherapy drugs through the catheter. Two groups of patients were recorded before surgery, Ridit test method, using SPSS13.0 statistical software for analysis. Results: The postoperative TCM syndromes, the total effective rate of efficacy, the incidence of adverse reactions and other indicators, compared with the control group were significantly improved. Conclusion: Tanreqing Injection as an adjuvant chemotherapy for interventional chemotherapy of lung cancer can effectively improve traditional Chinese medicine syndrome such as fever after operation, reduce the side effects of chemotherapy and improve the quality of life of patients with unique advantages, which deserves further study and clinical application Promote the application.