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目的:对柴胡疏肝散进行拆方研究,并观察各个组合抗小鼠运动性疲劳的效果。方法:将50只小鼠随机分为柴陈壳组、白芍组、香川组、柴胡疏肝散组、空白对照组,每组10只,采用逐渐递增游泳时间的训练模式建立运动性疲劳模型,4周后进行力竭游泳。观察小鼠体重、力竭游泳时间(Time)、乳酸(LA)、尿素氮(BUN)、超氧化物歧化酶(SOD)、丙二醛(MDA)、SOD/MDA等指标的变化。结果:各组小鼠的体重、LA、SOD、SOD/MDA,没有统计学差异(P>0.05);柴胡疏肝散组力竭游泳时间最长(P<0.05),其次为柴陈壳组,与其他3组比较有统计学差异(P<0.05);柴胡疏肝散组小鼠BUN含量最低(P<0.05);柴胡疏肝散组MDA含量最低(P>0.05),柴陈壳组MDA含量最高(P<0.05)。结论:柴胡疏肝散整方抗小鼠运动性疲劳效果最佳,可能是通过清除LA、降低BUN达到缓解运动性疲劳,提高运动耐力的作用。
OBJECTIVE: To study the effects of Chaihu Shugan San on disassembling and observing the effects of various combinations of anti-mouse exercise-induced fatigue. Methods: Fifty mice were randomly divided into Chai Chen shell group, Baishao group, Xiangchuan group, Chaihu Shugan powder group and blank control group, with 10 rats in each group. Exercise fatigue was established by training mode with gradual increasing swimming time Model, after 4 weeks of exhaustive swimming. The changes of body weight, time spent swimming, lactate (LA), blood urea nitrogen (BUN), superoxide dismutase (SOD), malondialdehyde (MDA) and SOD / MDA were observed. Results: The body weight, LA, SOD, SOD / MDA in each group had no statistical difference (P> 0.05); the Chaihu Shugan San group had the longest time of exhaustion swimming (P <0.05) (P <0.05). The content of BUN in Chaihu Shugan Powder group was the lowest (P <0.05), while that in Chaihu Shugan Powder group was the lowest (P> 0.05) The content of MDA in Chen shell group was the highest (P <0.05). Conclusion: Chaihu Shugan Powder has the best effect on exercise-induced fatigue in mice, which may be through the removal of LA, reducing BUN to relieve sports fatigue and improve exercise tolerance.