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为制备一种高效抗菌生物材料,以生物可降解材料聚(3-羟基丁酸酯-co-4-羟基丁酸酯)(P(3HB-4HB))和聚己二酸/对苯二甲酸丁二酯(PBAT)为基材,合成了一种新型含有季铵基团的卤胺抗菌剂单体;采用静电纺丝技术制备出P(3HB-4HB)/PBAT纳米纤维膜;利用电子束辐射技术将合成的单体接枝共聚到纳米纤维膜,最后经次氯酸钠氯化得到抗菌纤维膜。探讨了P(3HB-4HB)、PBAT组成对纤维膜表面形貌的影响,以及辐射量、单体浓度对纤维膜含氯量的影响,同时分析了抗菌纤维膜的耐紫外稳定性、储存稳定性。结果表明:P(3HB-4HB)/PBAT抗菌纳米纤维膜在5 min内即可将金黄色葡萄球菌和大肠杆菌全部杀死,显示出优异的抗菌性能,实现了卤胺抗菌剂和化学惰性材料的共价键合作用,有望应用于食品包装、生物医学等领域。
To prepare a highly effective antibacterial biomaterial, biodegradable materials poly (3-hydroxybutyrate-co-4- hydroxybutyrate) (P (3HB-4HB)) and polyadipate / terephthalate P (3HB-4HB) / PBAT nanofiber membrane was prepared by electrospinning technique using electron-beam irradiation technique (PBAT) as the substrate, a new type of halamine amine antibacterial monomer containing quaternary ammonium groups was synthesized. The synthesized monomer was grafted to the nanofiber membrane, and finally the sodium hypochlorite was chloridized to obtain the antibacterial fiber membrane. The effects of P (3HB-4HB) and PBAT composition on the surface morphology of fiber membrane and the effect of radiation and monomer concentration on the chlorine content of the membrane were discussed. The UV stability, storage stability Sex. The results showed that P (3HB-4HB) / PBAT antibacterial nanofibers could completely kill Staphylococcus aureus and Escherichia coli within 5 min, which showed excellent antibacterial properties and achieved the performance of haloamine antibacterial agent and chemically inert material Covalent bonding, is expected to be used in food packaging, biomedicine and other fields.