补体C1q肿瘤坏死因子相关蛋白9(CTRP9)属于CTRP超家族成员,与APN的结构相似。CTRP9多由脂肪组织合成分泌,也有部分来源于心肌组织及血管基质细胞,CTRP9与急性冠脉综合征(ACS)密切相关。CTRP9可以通过影响相关危险因素(如高血压、糖尿病、肥胖等)降低ACS的发病率。CTRP9在心肌梗死后可通过抑制炎症反应、氧化应激减少心肌梗死面积和降低缺血后再灌注损伤,通过抑制平滑肌细胞增殖迁移、新生内皮的形成和心室重构来改善ACS的预后。本文就近年来国内外有关CTRP9在ACS中的作用的研究进展进行系统阐述。 Complement CIq tumor necrosis factor-related protein 9 (CTRP9) is a member of the CTRP superfamily and is structurally similar to APN. CTRP9 mostly by the synthesis and secretion of adipose tissue, but also some from the myocardial tissue and vascular stromal cells, CTRP9 and acute coronary syndrome (ACS) are closely related. CTRP9 can reduce the incidence of ACS by influencing related risk factors (such as hypertension, diabetes, obesity, etc.). CTRP9 can improve the prognosis of ACS by inhibiting the inflammatory reaction, reducing the area of ​​myocardial infarct and reducing the post-ischemic reperfusion injury after myocardial infarction. It can inhibit the proliferation and migration of smooth muscle cells, the formation of neonatal endothelium and ventricular remodeling. This article systematically expounds the research progress on the role of CTRP9 in ACS at home and abroad in recent years.