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文收集了接受体外受精－胚胎移植（ＩＶＦ－ＥＴ）的子宫内膜异位症患者３２例，包括曾经丹那唑治疗２１例（丹那唑组）和孕激素或ＧｎＲＨ类似物治疗１１例（激素组），并以因单纯输卵管疾病接受ＩＶＦ－ＥＴ者２１例作对照组，分析ＩＶＦ－ＥＴ的各项参数。结果：丹那唑组的ｈＣＧ注射前血清Ｅ２，卵泡直径＞１５ｍｍ卵泡数和卵子受精率显著低于对照组（Ｐ＜０．０５，Ｐ．＜０．０１和Ｐ＜０．０５），而激素组与对照组相比，差异均无显著性。提示丹那唑可能妨碍卵泡发育，降低卵子质量而影响卵子受精。对于拟接受助孕技术的子宫内膜异位症患者宜选用孕激素或ＧｎＲＨ类似物制剂治疗。
Thirty-two patients with endometriosis undergoing IVF-ET were enrolled, including 21 treated with danazol (danazol) and 11 with progestin or GnRH analogues (hormone group ), And simple fallopian tube disease received IVF-ET in 21 cases as a control group, analysis of IVF-ET parameters. Results: Serum E2, the number of follicles> 15mm follicles and egg fertilization rate in the danazol group were significantly lower than those in the control group (P <0.05, P <0.01 and P <0.05) Compared with the control group, the difference was not significant. Danazol may hinder follicular development may affect the quality of the egg and affect the fertilization of the egg. Progesterone or GnRH analogue preparations should be used in patients with endometriosis intended to receive assisted pregnancy.