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目的 了解乳腺癌组织 ER、 PR及 C- erb B- 2癌基因蛋白表达与腋窝淋巴结转移之间的相关性。方法 用免疫组化 SP法测定 91例乳腺癌及 2 0例乳腺良性病变组织 ER、PR及 C- erb B- 2癌基因蛋白表达。结果 C- erb B- 2癌基因蛋白与淋巴结转移存在正相关 ;ER、PR表达与 C- erb B- 2癌基因蛋白表达存在负相关 ;ER、 PR表达与淋巴结转移可能无直接相关 ;但是可能影响 C- erb B- 2癌基因蛋白阴性者的淋巴结转移。结论 C- erb B- 2癌基因蛋白阳性者易出现淋巴结转移 ;C- erb B- 2的表达情况能影响 ER、 PR受体表达与淋巴结转移的相关性
Objective To investigate the correlation between the expression of ER, PR, C-erb B-2 oncogene protein and axillary lymph node metastasis in breast cancer. Methods The expressions of ER, PR and C-erb B-2 oncogenes in 91 cases of breast cancer and 20 cases of benign breast lesions were detected by immunohistochemical SP method. Results There was a positive correlation between the expression of C-erb B-2 oncogene protein and lymph node metastasis. The expression of ER and PR was negatively correlated with the expression of C-erb B-2 oncogene protein. The expression of ER and PR might not be directly related to lymph node metastasis. Lymph node metastasis affecting C-erb B-2 oncogene-negative. Conclusions The positive expression of C-erb B-2 oncogene B-2 is likely to have lymph node metastasis. The expression of C-erb B-2 can affect the correlation between ER and PR receptor expression and lymph node metastasis