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伊米普利盐酸盐(Imidapril hydrochloride)系日本田边制药公司开发的无巯基结构的新型ACE抑制剂。本品系前体药物,口服给药后由消化道迅速吸收,在体内转化为二酸化物后显示活性。本品给药后对血中ACE活性的抑制效果可持续24小时以上。二酸化物的半减期为7～9小时。 53例轻～中度的原发性高血压患者口服本品,初期每日1次2.5mg,以后渐增至最高20mg,共给药4～10周。结果,判定为“下降”以上的有效率为73.6%。本品剂量
Imidapril hydrochloride is a novel thiol-free ACE inhibitor developed by Japan Tanabe Pharma. This product is a prodrug that is rapidly absorbed by the digestive tract after oral administration and is active after it has been converted to the diacid in the body. This product after administration of blood ACE inhibitory effect of sustainable 24 hours or more. Half-reduction of the diacid is 7 to 9 hours. 53 patients with mild to moderate essential hypertension oral administration of this product, the initial daily 2.5mg, gradually increased to a maximum of 20mg, a total of 4 to 10 weeks. As a result, the effective rate of “falling” or more was 73.6%. This product dose