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目的:针对4种丹参类注射剂在不同溶媒、不同药物浓度,对其所用冲管液剂量的影响,探索冲管液的安全使用剂量。方法:以4种丹参类注射液为研究对象,以与莫西沙星的配伍变化、吸光度、外观颜色变化为结局指标,基于紫外分光光度法,综合分析确定临床冲管液的安全使用剂量。结果:冲管速度为每分钟60滴(3 mL·min~(-1))时,4种丹参类注射剂冲管液剂量不能低于22 mL,冲管液安全使用剂量应在34~42 mL。结论:为保证临床用药的安全性,建议水溶性中药注射剂使用冲管液剂量范围为34~49 mL。
OBJECTIVE: To investigate the effect of different doses of Salvia injection on the amount of flushing fluid used in different solvents and different drug concentrations, and to explore the safe dosage of flushing fluid. Methods: Four kinds of Salvia miltiorrhiza injection were selected as the research objects, and the compatibility change, absorbance and appearance color change with moxifloxacin were taken as the outcome indexes. Based on the ultraviolet spectrophotometry, the safety dosage of clinical flushing fluid was determined by comprehensive analysis. Results: When the tube speed was 60 drops per minute (3 mL · min ~ (-1)), the dosage of four kinds of Danshen injection could not be less than 22 mL and the volume of flushing fluid should be 34 ~ 42 mL . Conclusion: In order to ensure the safety of clinical medication, it is suggested that the dosage of irrigating liquid for water-soluble Chinese medicine injection should be 34-49 mL.