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目的观察并比较区域性动脉灌注和静脉推注中５－氟脲嘧啶（５－ＦＵ）的吸收、分布和消除过程，为临床区域性动脉灌注化疗提供实验室依据。方法将Ｗｉｓｔａｒ大鼠随机分为全身静脉给药组和区域性动脉灌注组，用高效液相色谱法分别测定两组血浆和胰腺组织中的５－ＦＵ浓度，并计算穿透指数和治疗优势度。结果静脉推注组胰腺组织中５－ＦＵ的最大浓度（Ｃｍａｘ）为８．４２ｕｇ／ｇ，存留时间为５０ｍｉｎ；区域性动脉灌注组胰腺组织中５－ＦＵ的Ｃｍａｘ为２０．００ｕｇ／ｇ，存留时间为９０ｍｉｎ，皆明显高于静脉推注组（Ｐ＜０．０５）。治疗优势度为２．４２。结论区域性动脉灌注５－ＦＵ能提高胰腺组织中５－ＦＵ浓度，延长胰腺癌组织和转移灶在５－ＦＵ中的暴露时间，改善治疗效果。
Objective To observe and compare the absorption, distribution and elimination of 5-fluorouracil (5-FU) in regional arterial infusion and intravenous injection, and provide laboratory evidence for clinical regional arterial infusion chemotherapy. Methods Wistar rats were randomly divided into systemic intravenous administration group and regional arterial perfusion group. The concentrations of 5-FU in plasma and pancreatic tissue were measured by high performance liquid chromatography, and the penetration index and therapeutic dominance were calculated. . Results The maximum concentration of 5-FU (Cmax) in the pancreatic tissue was 8.42μg/g in the intravenous injection group and the survival time was 50min. The Cmax of 5-FU in the pancreatic tissue in the regional arterial infusion group was 20.00ug/g. The time was 90 min, both significantly higher than the intravenous injection group (P<0.05). The treatment dominance is 2.42. Conclusion Regional arterial infusion of 5-FU can increase the concentration of 5-FU in pancreatic tissue, prolong the exposure time of pancreatic cancer tissue and metastasis in 5-FU, and improve the therapeutic effect.