甲状腺肿是常见病且多为良性,一般认为单个孤立的甲状腺肿恶性发生率相当高,大约为20%～30%,而临床上扪及为弥漫性增大的甲状腺肿则较少被怀疑为恶性。本文作者旨在了解弥慢性甲状腺肿发生肿瘤和恶性肿瘤的危险性。病人和方法作者从1981年9月至1987年8月进行为期6年的前瞻性研究。所有到该机构就诊的甲状腺肿患者均列为研究对象。根据临床检查结果,将甲状腺肿分为孤立性(仅有单个结节而其他甲状腺组织无肿大)和弥漫性(包括多结节性甲状腺肿)。所有患者常规进行一次或多次甲状腺穿剌细胞学检查。手术指征依据细胞学检查结果及临床特征。即使几次穿刺的细胞学检查结果中只有一次提示肿物为恶性或肿瘤性的,均进行甲状腺切除术。细胞学结果为非肿瘤性的,但存在临床有关危险因素如 Goiter is a common disease and mostly benign, generally considered a single isolated goiter malignant incidence is very high, about 20% to 30%, and clinically palpable as a diffuse increase in goiter was less suspected Vicious. The authors aim to understand the risk of developing tumors and malignancies in patients with chronic goiter. Patients and Methods The authors conducted a 6-year prospective study from September 1981 to August 1987. All patients with goiter who visited this institution were included in the study. According to the results of clinical examination, goiter was divided into isolation (only a single nodule and other thyroid tissue enlargement) and diffuse (including multiple nodular goiter). All patients underwent one or more routine thyroidectomy cytology. Surgical indications based on cytological findings and clinical features. Thyroidectomy is performed on only one of several punctuated cytological examinations, suggesting that the tumor is malignant or neoplastic. Cytology results are non-neoplastic, but there are clinically relevant risk factors such as