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目的:探讨乙型肝炎肝硬化患者血清可溶性细胞间黏附分子-1(soluble intercellular adhesion molecule-1,sICAM-1)、白细胞介素(interleukin,IL)-18的变化及其临床意义。方法:采用ELIAS法对60例乙型肝炎肝硬化患者(肝硬化组)和30例健康体检者(对照组)血清sICAM-1、IL-18水平进行检测。结果:肝硬化组血清sICAM-1,IL-18水平高于对照组(P<0.01)。肝硬化Child C级组血清sICAM-1,IL-18水平高于Child A级组和B级组,Child B级组高于Child A级组,差异均有统计学意义(P<0.01)。肝硬化组血清sICAM-1,IL-18水平与凝血酶原活动度、白蛋白呈负相关,与总胆红素呈正相关,与丙氨酸转氨酶无相关性。血清sICAM-1水平与IL-18呈正相关。结论:sICAM-1,IL-18水平在一定程度上反映肝细胞损伤程度和肝硬化严重程度,可为临床诊治、评判预后提供依据。
Objective: To investigate the changes of serum soluble intercellular adhesion molecule-1 (sICAM-1) and interleukin (IL) -18 in patients with hepatitis B cirrhosis and its clinical significance. Methods: The levels of serum sICAM-1 and IL-18 in 60 patients with cirrhosis (cirrhosis) and 30 healthy controls (control group) were detected by ELIAS. Results: The levels of serum sICAM-1 and IL-18 in cirrhosis group were higher than those in control group (P <0.01). The levels of serum sICAM-1 and IL-18 in Child C group were higher than those in Child A group and B group, and Child B group was higher than Child A group (P <0.01). Serum levels of sICAM-1 and IL-18 in cirrhotic patients were negatively correlated with prothrombin activity and albumin, positively correlated with total bilirubin and no correlation with alanine aminotransferase. Serum sICAM-1 levels were positively correlated with IL-18. CONCLUSIONS: The levels of sICAM-1 and IL-18 reflect the extent of hepatocellular injury and the severity of liver cirrhosis to a certain extent, which may provide evidence for clinical diagnosis and prognosis.