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目的:观察米索前列醇预防剖宫产产后出血的临床疗效。方法:选择2007年12月～2010年5月桐庐县妇幼保健院足月剖宫产的产妇96例,随机分为实验组和对照组各48例,实验组在胎儿娩出后即口服或舌下含化米索前列醇200μg,术毕时肛塞米索前列醇200μg;对照组在胎儿娩出后立即宫体注射催产素20 U,再静滴催产素20 U。观察比较两组产妇不同时间出血量及两组术中生命体征的变化情况。结果:实验组产后2 h及24 h的出血量明显少于对照组,差异有统计学意义(P<0.05),且产后出血的发生率,实验组也少于对照组(P<0.05)。但两组产妇用药前后血压、脉搏、血氧饱和度等生命体征无统计学变化(P>0.05)。结论:应用米索前列醇预防剖宫产产后出血疗效确切,用药方便、安全、吸收快,持续时间长,特别适合在基层医院使用。
Objective: To observe the clinical efficacy of misoprostol in preventing bleeding after cesarean section. Methods: A total of 96 maternal women undergoing full-term cesarean section in Tonglu MCH from December 2007 to May 2010 were randomly divided into experimental group and control group (n = 48). The experimental group received either oral or sublingual Containing misoprostol 200μg, surgery at the time of anal plug misoprostol 200μg; control group immediately after delivery of oxytocin in the uterine body injection of 20 U, and intravenous infusion of 20 U. Observe and compare the blood loss of maternal at different time and the changes of vital signs in the two groups. Results: The bleeding volume of experimental group was significantly less than that of control group at 2 h and 24 h postpartum, the difference was statistically significant (P <0.05). The incidence of postpartum hemorrhage was also lower in experimental group than in control group (P <0.05). However, before and after the two groups of maternal medication blood pressure, pulse, oxygen saturation and other vital signs no statistically significant changes (P> 0.05). Conclusion: The application of misoprostol to prevent bleeding after cesarean section is effective, convenient, safe, fast absorption and long duration. It is especially suitable for use in primary hospitals.