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口服避孕片1号(复方炔诺酮片)为我国法定的避孕药之一。本片系由适宜辅料制成片芯,外包含炔诺酮与炔雌醇的糖衣制成(每片含炔诺酮0.625mg,炔雌醇0.035mg)。亦有产品制成纸型膜片。对本片及同类制剂中微量炔雌醇的测定尚缺乏简便准确的方法。中国药典1977年版对本片仅规定测定炔诺酮一项。由于炔雌醇的生理活性较强,避孕片中炔雌醇的分析问题亟需解决。我们根据炔雌醇在无水乙醇中具有紫外荧光的性质,其激发峰为288nm,荧光峰为307nm,
Oral contraceptive tablets No. 1 (compound norethindrone tablets) is one of the statutory contraceptives in our country. The film is made of suitable excipients core tablets, norethindrone and ethinylestradiol icing clothes (each containing norethindrone 0.625mg, ethinyl estradiol 0.035mg). There are also products made of paper-type diaphragm. The film and similar preparations trace ethinyl estradiol measurement is still lacking a simple and accurate method. Chinese Pharmacopoeia 1977 edition of the film only provides for the determination of a norethindrone. Due to the strong physiological activity of ethinylestradiol, the problem of ethinylestradiol analysis in contraceptives needs to be solved urgently. According to ethinylestradiol in anhydrous ethanol with UV fluorescence properties, the excitation peak was 288nm, the fluorescence peak was 307nm,