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目的观察老年高血压病患者血尿酸,血脂,胰岛素抵抗指数和内生肌酐清除率等相关因素,探讨血尿酸在老年高血压病患者中的临床意义。方法老年高血压病组78例(A组),中青年高血压病组57例(B组),老年健康对照组41例(C组)。测量体质量指数(BMI),腰围(WC),腰臀比(WHR),检测血尿酸(SUA),总胆固醇(TC),三酰甘油(TG),高密度脂蛋白胆固醇(HDL-C),低密度脂蛋白胆固醇(LDL-C),空腹血糖(FBG),空腹胰岛素水平(FIn),计算胰岛素抵抗指数(HOMA-IR),血肌酐(Scr),计算内生肌酐清除率(Ccr)。结果高尿酸血症发生率分别为A组:23%,B组:28%,C组:2%。A组与C组比较,A组BMI、WHR、SUA、TG、TC、SBP、DBP、FIn、HOMA-IR均明显升高,A组Ccr、HDL-C低于C组,具有统计学意义(P<0.05);A组与B组比较,A组WHR、FIn、HOMA-IR、Ccr、DBP低于B组,具有统计学意义(P<0.05)。结论高血压病患者高尿酸血症发生率明显升高,血尿酸可作为高血压病患者临床评估的重要指标之一。
Objective To observe the related factors such as serum uric acid, lipids, insulin resistance index and endogenous creatinine clearance rate in elderly patients with essential hypertension to explore the clinical significance of serum uric acid in elderly patients with hypertension. Methods A total of 78 elderly patients with hypertension (group A), 57 patients with middle-aged hypertension (group B) and 41 healthy controls (group C). Body mass index (BMI), waist circumference (WC), WHR, SUA, TC, triglyceride, HDL- (LDL-C), fasting blood glucose (FBG), fasting insulin (FIn), calculated insulin resistance index (HOMA-IR) and serum creatinine (Scr) . Results The incidences of hyperuricemia were 23% in group A, 28% in group B and 2% in group C, respectively. Compared with group C, the levels of BMI, WHR, SUA, TG, TC, SBP, DBP, FIn and HOMA-IR in group A were significantly increased, while those in group A were lower than those in group C P <0.05). Compared with group B, the WHR, FIn, HOMA-IR, Ccr and DBP in group A were lower than those in group B (P <0.05). Conclusions The incidence of hyperuricemia in hypertensive patients is obviously increased. Serum uric acid may be used as one of the important indexes in clinical evaluation of patients with essential hypertension.