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目的评价输注血浆抢救治疗重症急性有机磷农药中毒(AOPP)的疗效。方法将采用常规疗法配合输注血浆治疗的32例AOPP患者作为治疗组,将同期,中毒程度相近而单纯采用常规疗法的32例AOPP患者作为对照组,比较两组疗效。结果治疗组患者的恢复时间,呼衰,心衰,休克改善时间、住院时间明显短于对照组,其治愈率,预后明显优于对照组。结论基层医院应用血浆抢救治疗重症AOPP,可以促进有机磷(OP)的清除,直接补充新生的胆碱酯酶(CHE),恢复CHE的活性,防治多器官功能障碍综合征(MODS),降低病死率。
Objective To evaluate the efficacy of transfusion plasma rescue in the treatment of severe acute organophosphorus pesticide poisoning (AOPP). Methods Thirty-two patients with AOPP treated by conventional therapy and infusion of plasma were enrolled in this study. Twenty-two patients with AOPP who were treated with conventional therapy at the same period and with similar degree of poisoning were selected as the control group. The curative effect was compared between the two groups. Results The recovery time, respiratory failure, heart failure, shock improvement time and hospital stay in the treatment group were significantly shorter than those in the control group. The cure rate and prognosis of the treatment group were significantly better than those of the control group. Conclusion The application of plasma salvage therapy in primary hospitals can promote the removal of organophosphorus (OP), direct replacement of neonatal cholinesterase (CHE), restoration of CHE activity, prevention and treatment of multiple organ dysfunction syndrome (MODS) and reduction of mortality rate.