目的:探讨高效液相色谱法同时测定黄酒中安赛蜜、苯甲酸、山梨酸、糖精钠的方法。方法:样品经沉淀、调节pH值、超声提取、离心、过滤后,进液相色谱仪检测。结果:方法检出限均小于0.005 g/kg,相对标准偏差在1.5%～4.4%之间,加标回收率在90%～100%。结论:方法灵敏、准确、重复性好且操作简便。 Objective: To study the simultaneous determination of acesulfame, benzoic acid, sorbic acid and sodium saccharin in rice wine by high performance liquid chromatography. Methods: The sample was precipitated, pH was adjusted, ultrasonic extraction, centrifugation, filtration, liquid chromatography. Results: The detection limits were all less than 0.005 g / kg, the relative standard deviations were between 1.5% and 4.4%, and the recoveries were between 90% and 100%. Conclusion: The method is sensitive, accurate, reproducible and easy to operate.