经皮雌二醇(E_2)治疗缓解更年期症状的短期观察已有报道。本文报告对57例绝经妇女用雌激素长期治疗期间的生物学和代谢变化等方面的观察。这些妇女闭经均超过6个月、有子宫、无激素治疗禁忌、停用外源性激素超过30天,均表现雌激素水平不足、血清E_2低于93pmol/L,进行基础指标测定后开始周期治疗(28天为一周期)。E_2用经应治疗仪每天0.1mg依次从下腹、髋部、臀或股部每隔 Short-term observations of percutaneous estradiol (E_2) treatment to alleviate menopausal symptoms have been reported. This article reports the observation of the biological and metabolic changes in estrogen during the long-term treatment of 57 menopausal women. These women had amenorrhea for more than 6 months with uterus and no hormonal contraindications. Exogenous hormones were discontinued for more than 30 days, showing estrogen insufficiency, serum E 2 below 93 pmol / L, and periodic treatment following the baseline measurements 28 days for a period). E_2 with the treatment should be 0.1mg per day from the lower abdomen, hip, hip or hip at intervals