【摘 要】
：
考察了在溶出度试验中采用近红外光谱法(NIRS)监测药物溶出行为的可行性,以期为药品质量控制提供更多的替代方法。以包含叶酸和4种辅料的速释片为模型进行溶出试验,试验条件
论文部分内容阅读
考察了在溶出度试验中采用近红外光谱法(NIRS)监测药物溶出行为的可行性,以期为药品质量控制提供更多的替代方法。以包含叶酸和4种辅料的速释片为模型进行溶出试验,试验条件为:采用欧洲药典收载的桨法(apparatus 2),1 L溶出杯中装入Milli-Q水500 ml为溶出介质,温度(37±0.5)℃,转速50 r/min。NIRS原位测定是通过在傅里叶变换红外光谱仪上连接一个透反射探头,从而得到红外光谱。采用偏最小二乘
The feasibility of monitoring drug dissolution behavior by near infrared spectroscopy (NIRS) in the dissolution test was investigated in order to provide more alternatives for drug quality control. The dissolution test was carried out on the immediate release tablets containing folic acid and four excipients under the following conditions: apparatus 2 loaded with European Pharmacopoeia, 500 ml of Milli-Q water as the dissolution medium in a 1 L vessel, , Temperature (37 ± 0.5) ℃, speed 50 r / min. In situ measurements of NIRS are made by attaching a transreflective probe to a Fourier transform infrared spectrometer to obtain the infrared spectrum. Partial least squares
其他文献
“在纯电动汽车迟迟不能普及的情况下,混合动力车型无疑是很好的过渡产品,在这方面丰田一直走在业界前列,其高端品牌雷克萨斯也在全力推进混合动力车型的普及。”在混合动力
<正>永定河是流经北京的最大河流,有"北京母亲河"之称。历史上永定河汛期洪水肆虐,裹挟泥沙,威胁京师安全。清代各朝皇帝均关注和积极治理永定河,馆藏军机处、宫中全宗档案中
We demonstrated a unique synthesis approach of graphene(GR)-wrapped Ag_3PO_4/LaCO_3OH(APO/LCO)heterostructures by an in-situ wet chemical method. FESEM analysis
Metal-organic frameworks(MOFs)are a new class of crystalline porous materials with periodic network structures,which are formed by self-assembly between metal i
提出了采用双非线性硒化锌(ZnSe)晶体将高斯光束整形成局域空心光束(LHB)的新方案,根据惠更斯-菲涅耳衍射理论计算了不同厚度的ZnSe晶体和不同束腰半径的高斯光束条件下产生
2014年5月14日,兰州石化公司质检部门牵头组织,对新制定的6项水质助剂验收产品标准与分析计划、4项树脂新产品标准和1项橡胶新产品标准进行讨论。2014年前4个月,兰州石化已组
A strategy to prepare horizontally aligned single-walled carbon nanotubes(SWNTs) at moderate temperatures(≤600 ℃) were developed.Using ferocene as the catalys
日前,青岛重工联合中国黄金拓极采矿服务有限公司合作开发的系列现场混装乳化炸药车产品已成功完成2款样车的试制,第3款样车正在试制中。据介绍,现场混装炸药车是集原材料运
要做好地方文献的征集工作,既要制订切实可行的计划,更要争取社会各方的合作,图书馆不能孤军作战。
To do a good job collecting the local literature, it is necessary t
The crystal structure of 2-(2-((4-(pyridin-2-yl)pyrimidin-2-yl)disulfanyl)pyrimidin-4-yl)pyridinium hexafluorophosphate was obtained by X-ray single-crystal dif